Publications

Publications

Journal Article:

  • B. Loretz, N. Schneider-Daum, M. Windbergs, U. Schäfer, M. Schneider, C.-M. Lehr. Barriers and motivations for non-invasive drug delivery. Editorial for the Biological Barrier Special Issue in European Journal of Pharmaceutics and Biopharmaceutics. September 2017, 118, pp:1-2 doi: 10.1016/j.ejpb.2017.04.016
  • T.Benjamin, M.Baues, T. Ojha, D.Möckel, S.Koyadan V., J. Steitz, L.van Bloois, G. Storm, F. Kiessling, T. Lammers. "Sonoporation enhances liposome accumulation and penetration in tumors with low EPR." Journal of Controlled Release (02.2016) 30074-8.
  • T., Okan, T. Ojha, G. Storm, F.Kiessling, T. Lammers. "Targeting cellular and microenvironmental multidrug resistance." (2016): 1199-1202.
  • M. Colombo, L. Fiandra, G. Alessio, S. Mazzucchelli, M. Nebuloni, C. De Palma, K. Kantner, B. Pelaz, R. Rotem, F. Corsi, W.J. Parak, D. Prosperi. Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies. Nature Commun. 2016 DOI: 10.1038/ncomms13818. 
  • Saraiva, S. M., Castro-López, V., Pañeda, C., Alonso, M. J.;„Synthetic nanocarriers for the delivery of polynucleotides to the eye”., European Journal of Pharmaceutical Sciences,2017, 103, 5-18DOI: 10.1016/j.ejps.2017.03.001
  • Lazzari G., Couvreur P., Mura S.; ”Multicellular tumor spheroids: a relevant 3D model for the in vitro preclinical investigation of polymer nanomedicines”; Polymer Chemistry; 2017; DOI: 10.1039/c7py00559h
  • Sun Q, Ojha T, Kiessling F, Lammers T, Shi Y.” Enhancing Tumor Penetration of Nanomedicines”. Biomacromolecules. 2017 Mar 31; 18(5):1449-59. doi: 10.1021/acs.biomac.7b00068.
  • Ojha T, Pathak V, Shi Y, Hennink WE, Moonen CT, Storm G, Kiessling F, Lammers T. “Pharmacological and physical vessel modulation strategies to improve EPR-mediated drug targeting to tumors”. Advanced Drug Delivery Reviews. 2017 Jul 8. Doi: 10.1016/j.addr.2017.07.007

Manuscripts: 

 

  • SantalicesI., Gonella A, Torres D, Alonso M.J.; „Technological advances on the formulation of proteins using nanotechnologies” Journal of Drug Delivery Science and Technology,.In press.
  • Yasar H., Ho D.K., De Rossi C, Herrmann J., Gordon S., Loretz B., Lehr C.M.; "Starch-chitosan polyplexes: a versatile carrier system for anti-infectives and gene delivery"Molecular Pharmaceutics, submitted manuscript

  • Santalices I., Gonella A., Torres D., Alonso M.J.; "Advances in the formulation of proteins using nanotechnologies".  Journal of Drug Delivery and Technology, In Press.

 

Poster and oral presentations of the ESRs:

  • Lazzari,G.; Mura, S. ; Couvreur, P. Shedding lights on cancer cells and their microenvironment: in vitro 3D tumor model of pancreatic cancer for preclinical prediction of in vivo behavior of nanomedicines. XVIe Journèe de l’Ecole Doctorale “Innovaation Thérapeutique: du fondamental à l’appliqué”, Faculté de Pharmacie, Châtenay-Malabry, June  17, 2016 (Poster presentation)
  • Lazzari,G.; Mura, S.; Couvreur, P. Shedding lights on cancer cells and their microenvironment: in vitro 3D tumor model of pancreatic cancer for preclinical prediction of in vivo behavior of nanomedicines. Doc&PostDoc Day, Institute Galien UMR-8612, Orsay, June  20, 2016 (Poster presentation)
  • T. Ojha ’Priming tumor blood vessels and the tumor microenvironment to improve nanomedicine-mediated drug delivery’. 11th European Molecular Imaging meeting (EMIM 09.03.2016) in Utrecht (Netherlands). (Poster and oral presentation) 
  • T. Ojha ’Priming tumor blood vessels and the tumor microenvironment to improve nanomedicine-mediated drug delivery’. CLINAM conference in Basel and WMIC conference in New York. (Poster presentation)
  • S. Bisso, Brambilla D., Leroux J.-C., Calcium phosphate nanoparticles for the dual delivery of bisphosphonates and siRNA to cancer cells, 4th Bilateral ETH-Chalmers Workshop, ETH Hönggerberg, Zurich (CH). September 19-21, 2016. (Poster presentation)
  • Vinciguerra, D.; Couvreur, P.; Nicolas, J.Synthesis and evaluation of Dual-Functionalized polymer prodrug nanoparticles for anticancer therapy XVIe Journèe de l’Ecole Doctorale “Innovaation Thérapeutique: du fondamental à l’appliqué”, Faculté de Pharmacie, Châtenay-Malabry, June  17, 2016 (Poster presentation)
  • Vinciguerra, D.; Couvreur, P.; Nicolas, J. Synthesis and evaluation of Dual-Functionalized polymer prodrug nanoparticles for anticancer therapy Doc&PostDoc Day, Institute Galien UMR-8612, Orsay, June  20, 2016 (Poster presentation)
  • R. Edwards, F. Nicotra, B. La Ferla. Nanobiotechnologies for preclinical studies Glyconanoparticles for drug targeting and delivery BtBsDay2015 Abstract 1-15
  • R. Edwards, F. Nicotra, B. La Ferla Novel Therapeutic Opportunities using Glyconanoparticles for Carbohydrate specific intracellular Delivery XV Convegno-Scuola sulla Chimica dei Carboidrati Certosa di Pontignano , 19-22 JUNE 2016
  • Khiet Ho-Duy*,Hanzey Yasar*, Chiara De Rossi, Sarah Gordon, Brigitta Loretz and Claus-Michael Lehr. ‘Starch-Chitosan polyplexes as a versatile drug delivery platform with tunable release characteristics’. 6th HIPS Symposium, Recent Developments in Infection Research, Saarbrücken, June 29th, 2016 ((*) Co-first authors) (Poster presentation)
  • Xabi Murgia, Duy-Khiet Ho, Brigitta Loretz, Konrad Schwarzkopf, Ulrich Friedrich Schaefer, and Claus-Michael Lehr. ‘Nanoparticle transport through human undiluted tracheal mucus’. CLINAM European Foundation for Clinical Nanomedicine, June 26-29, 2016, Basel (Poster presentation)
  • Hanzey Yasar, Khiet Ho-Duy, Chiara De Rossi, Sarah Gordon, Brigitta Loretz and Claus-Michael Lehr. ‘Starch-Chitosan polyplexes as a novel, versatile drug carrier system for transfollicular vaccination’. GPEN2016, November 9-12, 2016 at the University of Kansas. (Poster presentation)
  • A. Cox,S. Mancini, L. Calabresi, F. Re, Exploiting physiological proteins to boost the Aβ clearance from the brain: implication for Alzheimer’s disease therapy, XIV FISV Congress, September 2016,  Rome, Italy
  • F. Re , A. Cox, Exploiting physiological proteins to enhance the blood-brain barrier crossing of nanoparticles. Workshop of the Italian Society of Biochemistry: New Frontiers of Biological Membranes, May 2016 Milan, Italy
  • Ho D.K, Martins Maia da Costa A.M., De Rossi C., de Souza Carvalho-Wodarz C., Loretz B, Lehr C.M.; ‘Polysaccharide Sub-Microcarrier for Anti-infectives Delivery. 13th Zsigmondy colloquium, April 5-7, 2017 at INM, Saarbrücken, Germany. poster presentation
  • Ho D.K, Yasar H., Martins Maia da Costa A.M., De Rossi C., Herrmann J, de Souza Carvalho-Wodarz C., Loretz B, Lehr C.M.; “Polysaccharides based Versatile Nano-carriers for Pulmonary Anti-infectives Delivery”. 44th Annual Meeting & Exposition of the Controlled Release Society, July 16-19, 2017, Boston, Massachusetts, U.S.A. poster presentation
  • Ho D.K,; Costa A, De Rossi C., de Souza Carvalho-Wodarz C., Loretz B., Lehr, C.M.; “Pulmonary Targeted Anti-infectives Delivery System of Chitosan-Cyclodextrin Based sub-MicroCarriers”. 7th HIPS Symposium on pharmaceutical sciences devoted to infection research, June 29, 2017, Saarbrucken, Germany. poster presentation
  • Ho D.K,; Costa A, De Rossi C., de Souza Carvalho-Wodarz C., Loretz B., Lehr, C.M.; ‘Versatile Polysaccharide Sub-Micro Coacervate for Antibiotics Delivery’. 21st Annual Meeting of The Controlled Release Society Germany Local Chapter, March 2-3, 2017, Marburg, Germany, poster presentation
  • Murgia X, Ho D.K, Loretz B., Friedrich Schaefer U., Lehr, C.M.; “Addressing the size-dependent mobility of nanoparticles through human tracheal mucus”. 21st Annual Meeting of The Controlled Release Society Germany Local Chapter, March 2-3, 2017, Marburg, Germany, poster presentation
  • Montefusco-Pereira C.V., Carvalho-Wodarz C., Lehr, C.M. “Growth of P. aeruginosa on a 3D Model of Cystic Fibrosis Bronchial Epithelia and Macrophages” COMPACT (IMI project) Scientific annual meeting, March 22-24, 2017, Saarbrücken, Germany, poster presentation
  • Ho D.K,; Costa A, De Rossi C, de Souza Carvalho-Wodarz C., Loretz B., Lehr, C.M. "Pulmonary Targeted Anti-infectives Delivery System of Chitosan-Cyclodextrin Based sub-MicroCarriers", HIPS Symposium June 29th, 2017. Poster presentation:
  • Ho D.K., Yasar H., Costa A., De Rossi C., Herrmann J., de Souza Carvalho-Wodarz C., Loretz B.,  Lehr C.M.; "Polysaccharides based versatile carriers for pulmonary anti-infectives delivery",44th Controlled Release Society (CRS) conference, July 16-19, 2017. Poster presentation:
  • Lazzari G., Mura S., Couvreur P.; ”Shedding lights on cancer cells and their microenvironment: in vitro 3D tumor model of pancreatic cancer for preclinical prediction of in vivo behavior of nanomedicines”; Doc & PostDoc Day 2017 of Institut Galien Paris-Sud, University Campus of Orsay (France), 9th June 2017, oral presentation
  • Bisso S.;“Calcium phosphate nanoparticles for the dual delivery of bisphosphonates and pDNA”, Swiss Pharma Science Day, Bern (CH), 22 August 2017. abstract and poster presentation
  • Colombo M.;"How the number of antibodies attached to colloidal nanoparticles affect tumour targeting and therapeutic effect? NanoInnovation 2017- Rome (Italy), September 26-29, 2017, oral presentation
  • Prosperi D.; "Dependence of in vivo tumor homing, localization and therapeutic effect of colloidal nanoparticles on the number of attached antibodies"- 15th World Medical Nanotechnology Congress, Osaka (Japan), October 18-19, 2017, oral presentation
  • Alonso M.J.; „La nanomedicina en terapias oculares” III Simposio Internacional Biomateriales y Superficie Ocular: Lentes de Contacto, 31 March 2017, Valencia, Spain, oral presentation
  • Alonso M.J.; „Nanocarriers that help drugs overcoming the corneal barrier.”  30 Years of Drug Delivery Research In Honour of Arto Urtti’s, June 2017, Kuopio, Finland, oral presentation
  • Alonso M.J.; „Formulation of biologicals using nanotechnology approaches”, International Conference on Nanomedicine and Nanobiotechnology  25-26 September 2017, Barcelona, Spain, oral presentation 

Outreach activity

  • Khiet Duy Hodid an oral presentation of the NABBA project during a visit of a Korean visitors group from Ewha Womans University, Pharmacy department (group of 1 Professor und 12 students from 1st or 2nd year pharmacy study finished.) to our Department.
  • Khiet Duy Hoparticipated in the MCAA General Assembly: Venice, 4-5 March 2016.
  • Rana EdwardsPress interview: La Repubblica Milano 01/10/2016- Page 1+7-Meet me Tonight Corriere della Sera Milano 03/10/2016 – Quotidiano- Page 1+3 Università degli Studi di Milano – Bicocca-Press office YouTube interview Dec 2, 2015
  • European Researcher’s night: Biotalentum as partner organisation took part in the European Researchers’ Night and had a poster introducing NABBA project.
  •  Daniele Vinciguerra and Rana Edwards took part in MeetMeTonight and presented their work.
  • Carlos Montefuscoattended the Summer School Molecular Medicine from the Interdisciplinary Center for Clinical Research of the University Hospital of Jena from August to September 2015.
  • Carlos Montefuscoattended the European Health Science Match 2016 that occurred at the Heidelberg Life Science Cluster.
  • Ho D.K., Loretz B., Lehr C.M. (inventors),Aminoglycoside derivatives and nano-assemblies thereof, including those with quorum sensing inhibitory functionFiled patent: EP17179011.6
  • Alonso M..J.;“Nanoengineered drug delivery for specialized therapies", 6th FIP Pharmaceutical Sciences World Congress, Stockholm, Sweden, May 2017, Invited Lecture 
  • Ho D.K.; „Drug delivery – using nano and micro technologies”, Denmark Technical University. Summer school in PhD Summer School
This project has received funding from the European Union’s HORIZON 2020 Programme for research, technological development and demonstration under grant agreement no. 642028 H2020-MSCA-ITN-2014